Immunology

Department of Immunology

The Department of Immunology provides a tertiary referral service for adults and children with any form of immune-mediated disease.

We offer ambulatory care (outpatient clinics) for adults and children, in-patient care, and consultation services.

In addition to general immunology clinics, we conduct subspecialty clinics in allergy (Dr Katrina Randall) and systemic vasculitis (Prof Matthew Cook and Dr Giles Walters, nephrologist).

Refer a patient

Patients must have a valid referral from their general practitioner or from another specialist.

All adult clinics take place on Level 2 of the Canberra Region Cancer Centre (Building 19) at Canberra Hospital.

Paediatric immunology clinics take place on Level 1 of the Centenary Hospital for Women and Children.

All available results from previous medical investigations should be provided.

Referrals can be faxed to: Immunology (02) 6174 5543

We are also happy to discuss arrangements for telemedicine follow-up consultations.

Contact us

Contact the Department of Immunology via the hospital switchboard on (02) 6244 2222

Find a specialist

Immunology staff specialists:

  • Professor Matthew Cook, MB BS PhD FRACP FRCPA. Head of Department
  • Professor Paul Gatenby, AM MB BS MSc FRACP FRCPA
  • Dr Carolyn Hawkins, MB BS MSc FRACP FRCPA
  • Dr Katrina Randall, MB BS PhD FRACP FRCPA

Clinical Trials

We are currently enrolling into the following trials:

  • BREVAS - Belimimab uin remission of vasculitis
  • BASE - Belimumab assessment of safety in SLE

Research

The Department of Immunology has a very active research program which has attracted continuous NHMRC funding for more than 10 years.

This effort focuses on understanding the genetic and cellular basis of autoimmunity and immune deficiency.

We run two major Australian studies of immune disease: lupus (Australian Point Mutation in SLE, APOSLE) and primary immune deficiency (Australian and New Zealand Antibody Deficiency Study, ANZADA).

In addition, we conduct research into understanding the genetic and cellular basis of sarcoidosis, vasculitis and other forms of autoimmune disease.

Patients with any of these conditions are eligible for enrolment.

This can be discussed with Professor Matthew Cook.

Recent Publications

2014

Lee C.E., Fulcher, D.A., Whittle. B., Chand. R., Fewings. N., Field. M., Andrews. D., Goodnow. C.C., Cook. M.C. Autosomal dominant B Cell deficiency with alopecia due to an mutation in NFKB2 that results in non-processible p100. Blood. 2014 Sep 18. blood-2014-06-578542. [Epub ahead of print].

Kane. A., Deenick. E.K.,Ma. C.S., Cook. M. C., Uzel.G., Tangye. S.G. STAT3 is a central regulator of lymphocyte differentiation and function. Curr Opin Immunol 28, 49-57. 2014

Ellyard.J.I., Jergen.R., Martin. J.L., Lee.A., Field.M.A., Jiang.S.H., Andrews. T.D., Goodnow. C.C., Chitow. J., Hertzog.P., Alexander S.I., Cook. M.C*., Vinuesa. C.G*. *Equal. Whole exome sequencing in severe early-onset SLE identifies a pathogenic variant in TREX1. Arthritis Rheumatol. 2014 Aug 19.

Altin.J.A., Daley.S.R., Howitt.J., Rickards.H.J., Batkin.A.K., Horikawa.K., Kumar.S., Wu.L.C., Tan.S.S., Cook.M.C*., Goodnow.C.C*. *Equal. Ndfip1 mediates peripheral tolerance to self and exogenous antigen by inducing cell cycle exit in responding CD4+ T cells. Proc Natl Acad Sci, USA 111 (6), 2067-2074. 2014.

Sabouri.Z., Schofield.P., Horikawa.K., Spierings. E., Kipling.D., Randall.K.L., Langley .D., Roome.B., Vazquez-Lombardi.R., Rouet. R., Hermes.J., Chan.T.D., Brink.R., Dunn-Walters.D.K., Christ.D., Goodnow.C.C. Proc Natl Acad Sci USA. 2014 June 24; 111 (25): E2567-75. Doi:10.1073/pnas.1406974111.Epub 2014 May 12.

2013

Chew C.Y.J., Sinha.U., Gatenby.P.A., DeMalmanche .T., Adelstein.S., Garsia.R., Hissaria.P., French. M., Wilson. A., Whittle.B., Kirkpatrick.P., Riminton.D.S., Fulcher.D.A., Cook.M.C. Autoimmunity in primary antibody deficiency is associated with PTPN22. J Allergy Clin Immunol 131:1130-1135, 2013.

Baird.M., Ang.S., Clark.I., Bishop.D., Oshima.M., Cook.M.C., Hemmings.C., Takaishi.S., Worthley.D., Boussioutas.D., Wang.T., Taupin.D. The unfolded protein response is activated in Helliobacter-induced gastric carcinogenesis in a non-cell autonomous manner. lab Invest. 93: 112-22, 2013.

Kumar.R., Gunaratne.D., Khan.S., Crawford.K., Cook.M.C., Tuck.R. Acute neuropsychiatric manifestations of anti-N-methyl-D-aspartate receptor encephalitis. Australas Psychiatry. 21:279-80. 2013.

Pratama.A., Ramiscal.R.R., Silva.D.G., Das.S.A., Anthanasopoulos.V., Fitch.J., Botelho.N.K., Chang.P.P., Hu.X., Hogan.J.J., Mana.P., Bernal.D., Korner.H., Yu.D., Goodnow.C.C., Cook.M.C. and Vinuesa.C.G. Overlapping functions of ROQUIN-1 and ROQUIN-2 in the repression of mRNAs controlling Tfh cell accumulation and systemic inflammation. Immunity 38:669-680, 2013.

Ives.M.L., Ma.C.S., Palendira.U., Chan.A., Bustamante.J., Boisson-Dupuis.S., Arkwright.P.D., Engelhard.D., Averbuch.D., Magdorf.K., Roesler.J., Peake.J., Wong.M., Adelstein.S., Choo.S., Smart.J.M., French.M.A., Fulcher.D.A., Cook.M.C., Picard.C., Durandy.A., Tsumura.M., Kobayashi.M., Uzel.G., Casanova.J.L., Tangye.S.G., Deenick.E.K., Signal transducer and activator of transcription 3 (STAT3) mutations underlying autosomal dominant hyper-IgE syndrome impair human CD8+T-cell memory formation and function. J Allergy Clin Immunol. 132, 400-411. 2013.

He.J., Tsai.L.M., Leong.Y.A., Hu.X., Ma.C.S., Chevalier.N., Sun.X., Vandenberg.K., Rockman.S., Ding.Y., Zhu.L., Wei.W., Wang.C., Karnowski.A., Belz.G.t., Ghali.J.R., Cook.M.C., Riminton.D.S., Veillette.A., Schwartzberg.P.L., Mackay.F., Brink.R., Tangey.S.G., Vinuesa.C.G., Mackay.C.R., Li.Z., Yu.D. Circulating precursor CCR7(lo)PD-1(hi) CXCR5+ CD4+ T cells indicate Tfh cell activity and promote antibody responses upon antigen reexposure. Immunity. 39:770-81. 2013.

Deenick.E.E., Avery.D.T., Chan.A., Berglund.L., Ives.M., Moens.L., Stoddard.J., Bustamente.J., Boisson-Dupuis.S., Tsumura.M., Kobayashi.M., Arkwright.P., Averbuch.D., Engelhard.D., Roesler.J., Peake.J., Wing.M., Adelstein.S., Choo.S., Smart.J., French.M.A., Fulcher.D.A., Cook.M.C., Picard.C., Durandy.A., Klein.C., Holland.S.M., Uzel.G., Casanova.J.L., Ma.C.S., Tangye.S.T. Naive and memory human B cells have distinct requirements for STAT3 activation to differentiate into Ab-secreting plasma cells. J Exp Med. 210:2739-53.2013.

da Silva.E.N., Randall.K.L. Omalizumab mitigates anaphylaxis during ultrarush honey bee venom immunotherapy in monoclonal mast cell activation syndrome. J Allergy Clin Immunol Pract. 2013 Nov-Dec; 1 (6):687-8. Doi: 10.1016/j.jaip.2013.07.004. Epub 2013.Sep 8.

Daley.S.R., Coakley.K.M., Hu.D.Y., Randall.K.L., Jenne.C.n., Limnander.A., Myers.D.R., Polakos.N.K., Enders.A., Roots.C., Balakishnan.B., Miosge.L.A., Sjollema.G., Bertram.E.M., Field.M.A., Shao.Y., Andrews.T.D., Whittle.B., Barnes.S.w., Walker.J.R., Cyster.J.G., Goodnow.C.C., Roose.J.P., Rasgrp1 mutation increases naive T-cell CD44 expression and drives nTOR-dependent accumulation of Helios+ T cells and autoantibodies. Elife. 2013 Dec 12;2:e01020

Rabbolini.D.J., Ange.N., Walters.G.D., Pidcock.M., Randall.K.L. Systemic capillary leak syndrome: recognition prevents morbidity and mortality. Intern med J. 2013 Oct; 43(10): 1145-7.

Crawford.G., Enders.A., Gileadi.U., Stankovic.S., Zhang.Q., Lambe.T., Crockford.T.L., Lockstone.H.E., Freeman.A., Arkwright.P.D., Smart.J.M., Ma.C.S., Tangye.S.G., Goodnow.C.C., Cerundolo.V., Godfrey.D.I., Su.H.C., Randall.K.L., Cornall.R.J. DOCK8 is critical for the survival and function of NKT cells. Blood. 2013 Sep 19;122(12): 2052-61.

Phillips.D.P.,Talaulikar.D., Hawkins.C.A., Hickman.P.E. Utilisation of sFLC assays - how well do we comply with guidelines? Int J Lab Haematol. 2013 Apr;35(2):200-10.